HTHSCI 2F03 Lecture Notes - Lecture 14: Inflammatory Bowel Disease, Diverticular Disease, Carcinoid
26 Dec 2020
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Inflammatory bowel disease: pathology and presentation 47. Colorectal carcinoma: ix, mx and prevention 55. Portion of intestine (the intussusception) is invaginated into its own lumen (the intussuscipiens) 2 ft from ileocaecal valve on antimesenteric border. Tc pertechnecate scan +ve in 70% (detects gastric mucosa) Viral infection / urti enlargement of mesenteric lns. Jaundice from biliary obstruction or liver mets. Diverse group of neuroendocrine tumours of enterochromaffin cell origin capable of producing 5ht. May secrete: 5-ht, vip, gastrin, glucagon, insulin, acth. Carcinoid syndrome suggest bypass of first-pass metabolism and is strongly assoc. c metastatic disease. Valve fibrosis: tricuspid regurg and pulmonary stenosis. Tumour outgrows blood supply or is handled too much massive mediator release. Median survival is 5-8yrs (~3yrs if mets present) Inflammation of the vermiform appendix ranging from oedema to ischaemic necrosis and perforation. Age: rare <2yrs, maximal peak during child, thereafter. Oedema ischaemia necrosis perforation. Visceral pain is not well localised cf. somatic pain.
