HTHSCI 2H03 Lecture Notes - Lecture 5: Fibrinolysis, Carboxylation, Protamine
29 Apr 2016
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Document Summary
Vessel spasms (are intentional), constricting the vessel and limiting blood ow to the site of injury to reduce hemorrhage. Platelets bind with high af nity to the damaged vessel activated platelets release adenosine diphosphate (adp) and thromboxane a2 which stimulate activation of new platelets, platelet aggregation and vasoconstriction. Thrombin is also produced, which converts brinogen into brin. Fibrin strands provide scaffolding that forms the clot. Clot formation occurs in ~ 6 minutes. Triggered when tissue thromboplastin is released from damaged cells (outside the circulation) Clot on the outside of the vessel. Triggered when collagen is exposed at the site of vascular injury to blood components. Clot on the inside of the vessel. Though some clots are therapeutic, it is best to get rid of it as fast as possible. Cells adjacent to the clot release tissue plasminogen activator (t-pa) which converts plasminogen into plasmin. Plasmin digests brin and destroys the clot. Occlusion of arterial vessels leads to mi & cva.
