HTHSCI 2H03 Lecture Notes - Lecture 1: Excipient, Ear Drop, Pharmacology
14 Sep 2016
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How these vary for each individual determines how they will respond. Topical: applying drug to the area of action: skin, inhalers, eye & ear drops. Enteral: involves the esophagus, stomach, and small and large intestines (i. e. gi tract: oral: most common & complex- lots of room for individual variability, rectal. Biological fluids consist mostly of water, a polar (ionized) liquid. Process takes time especially if drug is highly non-polar, slowing onset of action. If drug is highly water soluble (ionized) it can be administered by iv as it will dissolve in the blood o o. Intravenous- skips the process of absorption- fast onset can be expected. If drug is poorly water soluble (non-ionized, or fat-soluble) it cannot be administered iv. Oral administration is the most common form of drug administration. Most drugs are bound to excipients (particles) that either. Add bulk to tablet: -drug cannot be absorbed until it is free of excipients, it must be dissolved.
