ISCI 1A24 Lecture Notes - Lecture 18: Nuclear Localization Sequence, Signal Recognition Particle, Golgi Apparatus
29 Sep 2016
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Document Summary
Central dogma of cell biology (flow of info from dna to protein) Central dogma of cell biology dna to mrna to proteins. The endomembrane system: (endoplasmic reticulum and golgi apparatus) Small molecules (ex. ions, atp, amino acids) diffuse randomly through the cell. However, the movement of proteins is energy dependent work must be done. In the endomembrane system, proteins that are synthesized in the rough er move to the golgi apparatus for processing, and travel from there to the cell surface. Cis face of golgi apparatus facing endoplasmic reticulum. Trans face faces outside of cell (membrane) The signal hypothesis states that proteins bound for the endomembrane system have a zip code . The zip code , called the er signal sequence, directs growing polypeptide to the er. The er signal sequence binds to a signal recognition particle (srp) that then binds to a srp receptor in the er membrane (ribosomes make er appear.
