LIFESCI 3B03 Lecture Notes - Lecture 19: Oligomer, Angioplasty, Axoplasmic Transport
18 Mar 2017
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Angioplasty procedure and help people that might have it. The toxicity mediated by a particular receptor may not be necessarily involve direct binding of ab to it but could be due to an indirect modulation of receptor properties by ab, ie. by membrane association. Size of the deposits- there is oligomer formation and then the fibrils and then the formation of plaques. Early stages in the nucleation process (the formation of the aggregates) is what you are picking up in the medium. Anything that is more than a monomer is detected- suggests that oligomers have some detrimental effects at the cellular level. How does ab induce memory loss? attributed to small soluble ab oligomers (dimers to dodecamers) Decreased hippocampal ltp and altered memory function can be directly. Insoluble aggregates (fibriluar ab deposits) might contribute to neuronal injury (e. g local synaptic abnormalities and breakages of neuronal processes) Plaque formation and deposits: highly possible that you have oligomers there (more.
