LIFESCI 2C03 Lecture 6: Chapter-5-feb.-3lecture w/ supplemental info
4 Oct 2016
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Neurotransmitter binds to receptor and causes the response to have gtp bind. Binding of gtp to alpha subunit activated g-protein. When gtp hydrolyzed back to gdp it turns back into its inactive state. G-proteins couple or link that is happening in neurotransmitter receptor and what happens in postsynaptic response. Ionotropic would be much faster, in metabotropic there are a number of interveining steps making response slower: g3proteinscoupleneurotransmi0erbinding toregula8onofpostsynap8cionchannels What type of receptor does ach bind to on muscle at end plate. Take outside out technique and use that, can add neurotransmitters to bath solution and they can bind to binding site of protein molecule. Ach binds and see brief openings of the ach receptor as seen above (red lines) When have multiple ions that can pass through the channel the reversal potential is a combination of the equilibrium potential of permeant ions. As get values below reversal potential value you are getting a smaller and smaller driving force.
