LIFESCI 2A03 Lecture : L9.pdf
6 Apr 2013
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Turritopsis nutricul: a jelly sh-like hydrazoan, is the only animal known to be potentially immortal. The adult can revert back to a polyp stage (similar to larval stage) and develop anew. http://9e. devbio. com/preview_article. php?ch=2&id=6 http://www. biolbull. org/content/190/3/302. full. pdf+html. That differentiated cells can dedifferentiate and then form new cell types. Reprogramming: restore pluripotency in a differentiated cell state, e. g. asc to ipsc, from there they could (potentially) assume any cell type. Dedifferentiation: induce the differentiated cell to proliferate, a differentiated cell goes back to a less differentiated state, divides, and the redifferentiates to the same cell type. Reports were made of various differentiated tissues containing cells derived from bone marrow grafts (reviewed. Tosh and slack 2002; raff 2003; wagers 2004): radiation to destroy bone marrow (mice). 2001, philippe collas (nucleotech) published results that seem to show that some cells can be transformed into other types of cells.
