LIFESCI 2G03 Lecture Notes - Lecture 16: Methylation, Meiosis, Chromosome

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indigohornet100

21 Mar 2018

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Activator cannot interact with core promoter of igf2 = expression is off on maternal chromosome. This is because of ctcf, the repressor protein. Because of cpg island methylation, activator cannot bind, h19 gene silenced. *overall: igf2 is on, h19 is off, they cannot be on at the same time normally. Epigenetic effect whatever silences the maternal or paternal gene is not encoded in the dna. The factor is outside the gene, but is heritable. Methylation can be maintained across generations by methylase that recognize methyl groups on one strand and respond by methylating the opposite strand. Maternal homologue = un-methylated, paternal homologue = methylated. Methylated state is also replicated after dna replication has occurred. See addition of more methyl groups onto only the chromosome that already had methyl groups. End up with 2 cells that are epigenetic copies of each other (epigenetic state is replicated/ stable through mitotic division)

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Grade 9 Science – Lab Safety & Equipment Woksheet

Part A: Highlight ‘T’ for TRUE OR ‘F’ for FALSE for each of the following questions. (K - 35)

1. T F Broken glassware should be swept up immediately and placed in the garbage bin.
2. T F Eyeglasses or contact lenses are an acceptable substitute for googles during an experiment.
3. T F If you arrive at class to find a spilled liquid on your desk, you should assume it is water and wipe
it up with paper towels.
4. T F Students with long hair must tie it back when using Bunsen burners.
5. T F If you take too much of the chemicals needed for an experiment, put it back into the container you
got it from.
6. T F Class B fires are those related to electrical equipment.
7. T F Discard all solid waste by rinsing it down the sink.
8. T F You may consume food and drinks during a lab, as long as it is kept at a safe distance from
chemicals.
9. T F If asked to detect the odour of a chemical in the lab, the student should inhale a deep breath of the
chemical.
10. T F If your clothing were to catch on fire, your first step should be to STOP, DROP and ROLL.
11. T F When using a fire extinguisher, aim at the top of the fire. The chemical in the extinguisher will
fall and put out the flames.
12. T F When heating chemicals in a test tube, heat from the bottom up, aiming the test tube at the
ceiling, and keep the test tube still.
13. T F It is ok to take off my safety goggles if it’s just for a second while I write something down.
14. T F If any chemical makes contact with your eye, wash it immediately at the eyewash station for
fifteen minutes. If you should spill chemicals on your skin, place the affected area under water
immediately.
15. T F Always read through each activity before you begin.
16. T F If you are unsure about any part of the procedure for an experiment, you should figure it out
yourself. Asking the teacher for clarification will result in a lower mark due to lack of preparation.
17. T F It is acceptable to sit during very long experiments.
18. T F It is ok if I don’t know where the lab safety equipment is since I can just ask someone later.
19. T F Be sure to tell your teacher about any accident, broken equipment, or injury that occurs during
class; no matter how minor.
20. T F When working with chemicals, keep pens and pencils away from your mouth.
21. T F In warmer months, it is acceptable to wear sandals during an experiment.
22. T F Determine whether your equipment is cool enough to disassemble by placing the back of your
hand near it.
23. T F Loose-fitting, long-sleeved shirts should be worn during experiments to protect your arms from
burns and chemical splashes.
24. T F If you must retrieve materials during a lab, it is acceptable to leave your Bunsen burner unattended
as long as it is set to a yellow flame.
25. T F To avoid an injury when heating materials, always place a stopper or tight-fitting lid on the
container being heated.
26. T F If a student uses the last of the chemicals in an experiment, it is their responsibility to go into the
storeroom to retrieve an additional quantity of that chemical.
27. T F Always leave your work area clean and dry before leaving the lab and make sure equipment and
glassware is returned clean to its proper place.
28. T F Horseplay is O.K. during a lab as long as no one is getting hurt.
29. T F It is never advisable to place a thermometer in an open flame.
30. T F To cool hot glassware, run cold water over it.
31. T F Class A fires can be extinguished with water.
32. T F Class D fires must be extinguished with water.
33. T F Keep equipment away from the edge of the lab bench.
34. T F If your eye itches while you are working with chemicals, you should rub it with your hands.
35. T F WHMIS stands for warning hazardous materials information symbols.

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LIFESCI 2G03 Lecture Notes - Lecture 16: Methylation, Meiosis, Chromosome

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