LIFESCI 2N03 Lecture Notes - Lecture 8: Folate Deficiency, Thiamine Pyrophosphate, Casimir Funk
2 Feb 2016
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Document Summary
Discovered the health needs of vitamin c in british sailors. Fatigue, anemia, hemorrhaging, teeth loosening, softening of bones. Isolated an amine in rice nitrogen containing functional group. Discovered . providing an amine improved the health of thiamin deprived chickens. Referred to this amine as vital for life . therefore, we now have vital . Do not contribute to the body"s energy needs. 8 b-vitamins: b1 thiamin, b2 riboflavin, b3 niacin, pantothenic acid, biotin, folate, b6, b12. Absorbed directly through intestinal cells and into cv system. Vitamin b12 is stored more than other water soluble vitamins. Need daily ingestion of water-soluble vitamins (not stored) Example: vitamin c deficiency symptoms manifest after 20-40 days. Thiamin: part of the co-enzyme tpp (thiamin pyrophosphate, works with pdh. Deficiency: caused by a reduction in food intake, beriberi chronic thiamin deficiency, chronic weakness, weight loss, brown vs. white rice. Vitamin b2 - riboflavin: co-enzyme (fmn, fad, electron acceptor/transporter.
