LIFESCI 3AA3 Lecture Notes - Lecture 12: Glioblastoma Multiforme, Dna Replication, Cell Division
9 Dec 2018
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Document Summary
Cancer: diseases where abnormal cells divide w/o control & can invade other tissues; >100 types. Daughter cell damage (mutation), either: checkpoints detect error repair error, no repair = cell suicide or apoptosis. Cancer cells turn on genes that help them grow/divide & turn off tumor suppressors (prevent apoptosis) In dish limited growth: anchorage dependence. Cells continue dividing, mutation passed on and new mutations arise. Uncontrolled and accumulated cancer cell growth tumor formation. In dish excessive division: no anchorage dependence cells anchor to dish surfaces and divide. Grow in clumps: density dependent inhibition, no density-dependent inhibition. When cells form a complete single layer, they cells continue dividing beyond single layer stop dividing if some are scraped away, cells divide to fill gap and then stop again. 2 types of uncontrolled cell growth: benign tumors not cancerous, can be removed & don"t spread to other areas of body, malignant tumors cancerous; metastasis: invasion of nearby tissues, spread throughout body.
