MEDRADSC 1B03 Lecture Notes - Lecture 6: Anti-Nuclear Antibody, Autoimmune Disease, Autoantibody

• School: McMaster University
• Department: Medical Radiation Sciences
• Course: MEDRADSC 1B03
• Professor: sandra charbonneau

Document Summary

Invaders come into body (first exposure) and antibodies form. Invaders come into body (second exposure) and antibodies already there eliminate antigens. Production of antibodies (autoantibody) which attacks individual"s own tissue. Leads to inflammation and necrosis of tissue. Autoimmune disease: chronic inflammatory disease affecting many systems. Immune complex deposits throughout body in connective tissue leading to inflammation and necrosis. Vasculitis leading to ischemia leading to more inflammation leading to necrosis. Blood test: presence of ana"s (antinuclear antibodies) and le (lupus erythematosus) cells in serum. Glucocorticoid (prednisone): reduce immune response and inflammation. Results from a loss of function of one or more components of the immune system. Basic developmental failure somewhere in the system. Loss of immune response due to specific causes and can occur at anytime during the life span. Prophylactic measures needed: antibiotics given when an invasive procedure is going to be done chance of organisms lead to body .