MEDRADSC 2X03 Lecture Notes - Lecture 8: Mitosis, Red Blood Cell, Prostate Cancer
28 Jul 2019
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Lecture 8: how do our cells respond to radiation based on radiosensitivities, repair vs. Categories of cell damage from radiation: lethal. Outcome affected by environmental conditions: sublethal. Normally reversible, repairable as long as repair can occur prior to additional damage sustained. Occurs during d1 in the multitarget model (representative of the shoulder of the curve) Evidence points to damage of chromosomal dna as basis of radiation-induced lethality; saying dna is mainly the critical target. Associated mainly with asymmetrical exchange-type aberrations (ie rings, dicentrics, anaphase bridge) Typically the mode of radiation-induced death for vim cells; vim = vegetative intermitotic cells; vim cells are under the classification of type. Most of the death that takes place (most sensitive in mitosis) Can be demonstrated after a single irradiation of cells. Can increase surviving fraction for given dose by manipulating post-irradiation environment to conditions suboptimal for mitosis (ie depleted nutrients, change the temperature)
