MOLBIOL 3B03 Lecture Notes - Lecture 5: Nuclear Localization Sequence, Nuclear Transport, Nuclear Pore
5 Jan 2017
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Transcription and translation are compartmentally separated between nucleus and cytoplasm. Genome organized as a single dna molecule. Genes are compact and not split by intervening sequences. Dna makes rna makes proteins central dogma. Recombinant dna artificial dna molecules in which dna sequences not normally found together have been joined. Double stranded antiparallel double helix of deoxyribose sugars substituted with nitrogenous bases. Hydrogen bonds between complementary a, t and g, c - inter. Have directionality defined by the position of phosphate of deoxyribose carbons. Single stranded polymer of ribose sugars substituted with nitrogenous bases. Is directional defined by the position of phosphate on ribose carbons. Nuclear envelope is made up of inner and outer nuclear membranes, each a bilayer. Outer membrane is continuous with er, and can be studded with ribosomes. Each pore has about 100 different proteins that form the nuclear pore complex (npc) Nuclear fibrillary matrix is inside the ne and is structural support.
