NURSING 3PA2 Lecture Notes - Lecture 36: Cell Adhesion Molecule, Dendritic Cell, Proinflammatory Cytokine
10 Apr 2018
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Document Summary
T-lymphocytes: macrophages also release proteases, specifically matrix-metalloproteinase and cathapsins, cd4+ lymphocytes and b-cells, cd4 t-lymphocytes activate b-cells and b-cells are involved in antibody production. Pro-inflammatory cytokines: there is an increase in the following pro-inflammatory cytokines: o tnf- (tumeronecrosis factor alpha) Increases expression of adhesion molecules on leukocytes and endothelial cells. Up-regulates other pro-inflammatory cytokines like il-1 and il-6. It is especially increased during exacerbations and in persons with copd and associated weight loss o il-1 . Activates macrophages to secrete inflammatory cytokines, chemokines, and matrix- metalloproteinase: il-6. It is a link between innate and acquired immunity stimulates c-reactive protein release from the liver: il-32. Chemokines: induce leukocyte chemotaxis, specifically promoting neutrophil activation and migration. Growth factors: contribute to airway remodelling, dec. anti-inflammatory cytokines (i. e. il-10, cytokines can also have inhibitory or anti-inflammatory effects, one such cytokine is il-10, which is reduced in the sputum of persons with.
