NURSING 2LA2 Lecture Notes - Lecture 2: Mast Cell Stabilizer, Prostaglandin D2, Mast Cell
4 May 2016
School
Department
Course
Professor
Document Summary
Respiratory system: airway passages, lungs, associated blood vessels. Purpose: provide oxygen and carbon dioxide exchange between airway and blood. Respiration: three processes: ventilation the movement of air from the atmosphere into and out of the lungs. Diffusion- movement of gases between the alveoli and the capillaries [alveolar-capillary membrane] Co2 alveoli: expiration removal of co2. If respiration is impeded, gas exchange cannot occur, the body"s supply of oxygen becomes insufficient for its needs and co2 cannot be expelled from the blood. Asthma: chronic reactive airway disorder characterized by increased resistance to air flow due to episodic airway obstruction. Extrinsic atopic asthma , initiated by a type 1 hypersensitivity response to an extrinsic antigen. Antigen binds to mast cell degranulation release of histamine, leukotrienes, interleukins, prostaglandins inflammation & bronchospasm. Airway inflammation produces airway edema, epithelial injury, impaired mucociliary function. Intrinsic- non-atopic , initiated by diverse, non-immune mechanisms however, many have overlapping symptoms [intrinsic asthma is triggered by irritant receptors and vagal reflex.
