NURSING 2PF3 Lecture 3: Pathophysiology Module 3- COPD
8 Mar 2018
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Document Summary
Preventable, common disease in canada 700,000 adults (4. 44%) affects aboriginals at a higher rate. 4th leading cause of death in females, and 5th in males. Etiology: cigarette smoking is the leading cause 15-20% of smokers will get it. Smokers lose lung function at twice the rate of a non-smoker associated with increased mortality; active and passive implicated: adolescents who smoke inhibit maximal lung development. 80-90% of those diagnosed with copd have a history of smoking: genetics plays a role ex. Polymorphisms of genes that code for tnf, surfactant, proteases, hereditary deficiency of alpha-1 antitrypsin, and antiproteases: deficiency in alpha-1 antitrypsin may result in early onset and severe copd; worsened by smoking, multiple genetic and environmental factors; epigenetic factors. Copd: group of disorders that are characterized by airflow limitation. Chronic bronchitis: airway inflammation and obstruction of the major and small airways; chronic productive cough for at least 3 consecutive months over 2 consecutive years is required for clinical diagnosis.
