PHILOS 2D03 Lecture 7: Philosophy Lecture 7.docx
4 Feb 2014
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Document Summary
Medical research high quality knowledge safety efficacy systematic generalizable substantiated. Evidence based medicine (ebm) pyramid will be posted online. Systematic review (meta analyses) the cochrane collaboration best practice standards and guidelines. Informed consent competence provision of information understanding voluntariness. Rcts (randomized control trials) blinded someone or many people are unaware of what the intervention is for each person the person may not know if they are being given a placebo or the real medication randomized placebos. Therapeutic misconception conflict between aims of : research - generalizable knowledge clinical care - improve patient wellbeing high risk, low chance, very sick. 5% survival rate after 5 years stage 1 clinical trial safety testing of chemotherapeutic agent maximum tolerated dose of drug in humans . Thomas maximum tolerated dose riskier to help people with no other options equal risk maximum tolerated dose riskier maximum tolerated dose riskier.
