BIOL 2202 Lecture Notes - Lecture 9: Intracellular Receptor, Cell Signaling, Signal Transduction
27 Jun 2017
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Document Summary
Cells convert one type of signal (usually external) into an internal signal that is important for the cell. 4 ways that cells signal to one another (or receive signals) Secreted into the extracellular fluid note: autocrine signalling is where cells signal to themselves can promote the survival of cancer cells. Requires a membrane bound signal receptors and receptor on target cell. Response is restricted to neighbouring cells that are in contact. Effect of acetylcholine on 3 types of cells: heart pacemaker cell, salivary gland cell; same receptor but different intracellular pathway, skeletal muscle cell; different receptor but different intracellular pathway. Multiple signals can act on the sae cell. It is combination of these signals that determines the response. 2 ways that signals can result in behavioural changes. 1. fast response seconds to minutes: slow response minutes to hours. Changes in protein function (i. e opening of an ion channel or phosphorylation) Can be extracellular (hphil ligand) or intracellular (hf ligand)
