NURS 2004 Lecture Notes - Lecture 3: Spironolactone, Theophylline, Vitamin K
26 Jan 2017
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Interactions can occur whenever a patient takes more than one drug. Some interactions are intended and desired or unintended and undesired. Inhibitory- interactions that result in reduced drug effects. Reduced adverse effects (naloxone to treat morphine overdose) Creation of a unique response (alcohol with disulfiram) Never combine drugs in the same container without establishing compatibility. Most important and most complex mechanism in which drugs interact. Transmembrane protein that transports a wide variety of drugs out of cells: reduction or increased pgp. May be potentiative (morphine and diazepam) or. Drugs with overlapping toxicities should not be used together. Drug interactions have the potential to significantly impact the outcome of therapy. Risk for serious drug interaction is directly proportionate to the number of drugs a patient is taking. Interactions are especially important in drugs with low therapeutic index. Be aware of the possibility of illicit drug use. Adjust the dosage when metabolizing inducers are added or deleted.
