NSCI 323 Lecture Notes - Lecture 9: Ampa Receptor, Gria1, Gria2
17 Oct 2017
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Graph looking at the magnitude of the neuron and then normalized. Activates neurons to release glutamate to the downstream neuron to produce an excitatory response. Time for 10 minutes to get a stable baseline. Second arrow > mimics when significant events occur = series of neurons detect meaningful event. Glutamate builds up and adds on the response as the neurons keep firing. The epsps summate and it increases the chances that the postsynaptic neuron will reach the threshold for an action potential third arrow. Every time you stimulate normally, the response is bigger. Not more glutamate release but the same amount produces a bigger response in third arrow >> lasts for a long time. Consequence = postsynaptic response is bigger so there is a higher probability that it will reach threshold potential for an action potential. Ampa receptor changes the transmission level (why it"s stronger) Intracellular domain contacts other intracellular chemicals and enzymes >> where the action occurs.
