NSCI 323 Lecture Notes - Lecture 11: Nmda Receptor Antagonist, Nmda Receptor, Fear Conditioning
24 Nov 2017
School
Department
Course
Professor
Document Summary
Nmda is key in triggering the intracellular events leadings to ltp. Ltp is in black on graph transient state in between -> don"t care about the outcome there. Apv (ap-5) is an nmda receptor antagonist -> will block them, resulting in no ltp. Nmda receptor is necessary for ltp if nmda blocker is introduced after the induction protocol, Nmda receptors are not required to maintain ltp but necessary to induce it. No nmdars, no ltp induction in the hippocampus. In the presence of apv blocker there is no ltp. Removed the drug -> saw ltp replicated in many other areas of the brain including the amygdala. Not all ltp is nmda dependent but the dominant form is. Associative ltp is necessary and ltp dependent in vivo. Apv is applied locally in rat amygdala before and during pairing the shock with the tone the drug is dissolved in the cerebrospinal fluid. Calculate fear conditioning -> when the animal freezes.
