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Lecture 22

BCHM 316 Lecture Notes - Lecture 22: Metabolomics, Carbohydrate Metabolism, Adenosine


Department
Biochemistry
Course Code
BCHM 316
Professor
Glenville Jones
Lecture
22

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Lecture 22: Integration of Metabolic Pathways, Metabolic profiling (Metabolomics) Whole Body
Regulation of Metabolomics
Catabolism: breakdown of nutrients to make
energy
Anabolism: making building blocks, uses
energy
CATABOLISM
Energy Containing Nutrients
- Carbohydrates
- Fats
- proteins
Intermediates energy produced, reduced
- ADP+HPO4 2- → ATP
- NAD+ → NADH
- NADP+ → NADPH
- FAD → FADH2
Energy depleted products
- CO2
- H2O
- NH2
ANABOLISM
Precursor molecules
- Amino acids
- Sugars
- Fatty acids
- Nitrogenous bases
Intermediates energy absorbed, oxidized
- ATP →ADP+HPO4 2-
- NADH→ NAD+
- NADPH→ NADP+
- FADH2 → FAD
Cell Macromolecules
- Proteins
- Polysaccharides
- Lipids
- Nucleic acids
ATP has many high energy phosphate
bonds.
γ-β bond = -30.5 (ATP → ADP)
Β-α bond = - 32.8 (ADP→ AMP)
α-Adenosine bond= -14.2 (AMP→ Pi+
Adenosine)
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