BIOL 103 Lecture Notes - Lecture 4: Chronic Obstructive Pulmonary Disease, Myasthenia Gravis, Hbb
21 Oct 2017
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Platelets: cell fragments of megakaryocytes fibrinogen: for blood clotting. Genetics of clotting diseases factor xi located on x chromosome (hemophilia b) e. g. queen victoria had a lot of children. Physicians can use warfarin for patients that have easily clotting blood. Red blood cells erythrocytes carries oxygen to tissues. Bioconcave: increases surface area allows easy diffusion. No nucleus can carry more proteins that carry oxygen red blood cells cannot divide (differentiates from stem cells) glycoproteins abo in plasma membrane blood type: rh glycoproteins included also. Hemoglobin tetramer 2 beta globins and 2 alpha globins has 4 heme groups with iron. 300 million hemoglobins in each erythrocyte 10^9 oxygen molecules carried by each red blood cell fo(cid:396) (cid:373)ost pa(cid:396)t: he(cid:373)oglo(cid:271)i(cid:374)s ha(cid:448)e o(cid:454)(cid:455)ge(cid:374) o(cid:396) the(cid:455) do(cid:374)"t. One oxygen binds change in conformation easier for other 3 oxygen molecules to bind cooperativity to the binding. Diagnosis/ monitoring of chronic obstructive pulmonary disease (copd), asthma, cystic fibrosis etc.
