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BIOL 205 (111)
Lecture

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Department
Biology
Course
BIOL 205
Professor
Ian D Chin- Sang
Semester
Fall

Description
Key stages of meiosis and mitosis —Figure 2-15 correction n= polidy (number of chromosomes) c= content of DNA → Figure 2-15 says 4n but should be 4c to be more correct What patterns in a pedigree would reveal autosomal recessive inheritance? (1)  generally the disorder appears in the progeny of unaffected parents and (2)  the affected progeny include both males and females. - examples: Cystic Fibrosis, PKU, Albinism Homozygous recessives from inbreeding → affected personineachgeneration: usuallydominant a/a a/a a/a a/a A/a a/a A/a a/a a/a a/a A/a a/a A/a What patterns in a pedigree would reveal autosomal dominant inheritance? (1) The phenotype tends to appear in every generation of the pedigree. Parents of affected children show the phenotype. (2)  Half the offspring affected (3) Affected fathers or mothers transmit the phenotype to both sons and daughters. examples: pseudoachondroplasia Pseudoachondroplasia genotype(D): type of dwarfism D is null allele +/+ unaffected D/+ Pseudoachondroplasia -in regards to height:Dallele is DOMINANT -in regards to living:Dallele is RECESSIVE (two copies D/D Lethal? = dead) Behaves similar to the Mouse T (T-box) mutation Note: Piebald, Polydactyly (more than ten fingers), and Huntinson’s Disease also autosomal dominant. But the nature of the dominant mutation is different from dominant mutations due to haploinsufficient gene. We’ll come back to this. Ifon exame says:rare genetic disorder → assumed people coming into famnot carriers Autosomal Polymorphisms Brown vs. blue eyes* Pigmented versus blonde hair Chin dimples vs. none Widow’s peak vs. none Attached vs. free ear lobes • in natural populations of organisms, a polymorphism is the coexistence of two or more common phenotypes of a character • the alternative phenotypes of a polymorphism (morphs) are often thought to be inherited as alleles of a single autosomal gene in the standard Mendelian manner • the interpretation of pedigrees for polymorphisms is somewhat different from that of rare
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