BIOL 334 Lecture Notes - Lecture 8: Hexokinase, Glucagon, Reagent

• School: Queen's University
• Department: Biology
• Course: BIOL 334
• Professor: William Charles Plaxton

Document Summary

Main allosteric effectors in top down control in animal cell: function, amp to atp, inhibition and activation of pfk/ pk is dependent on atp levels, inhibition = high atp levels, activation = low atp levels. Hexokinase (hk) glucose + atp > glucose-6-p + adp. Atp-phosphofructokinase (pfk) fructose-6-p + atp > fructose-1, 6-p2 + adp. Pyruvate kinase (pk) phosphoenolpyruvate + adp > pyruvate + atp. Ppi-pfk fructose-6-p + ppi > fructose-1,6-p2 + pi. Pepc phosphoenolpyruvate + hco3- > oxaloacetate + pi. Hepatocyte (liver cell) glycolysis vs gluconeogenesis (g. n. g. : pancreas secretes glucagon (from starvation signal), is a peptide hormone, from low blood [glucose, glucagon binds to hepatocyte receptors, activation of intracellular adenylyl cyclase. [camp: pk-a, promotion of g. n. g. and prevents futile cycle between pep, pyruvate, and. Reduction of flux through glycolysis: decreases the following: [fru2,6p2] and causes atp-pfk to be less active. Diagram of molecular mechanisms contributing to metabolic arrest in stress-tolerant animals.