BMED 380 Lecture Notes - Lecture 5: Cancer Immunology, Adaptive Immune System, Innate Immune System
27 Nov 2017
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Document Summary
The immune system can help destroy cancer cells and influence its development. Can increase aggressiveness of malignant cells through immunoediting. Immunoediting = immune system both destroys and acts as a selective pressure for cancer cells. Immune system has a critical role in controlling cancer through the innate and adaptive immune system responses this represents a broader concept called cancer immunoediting. Inflammation can occur in acute (short term) and chronic (long term) in the body. Short term/ acute inflammation: associated with protective adaptive immune response. Long term/ chronic inflammation: associated with tumourigenesis. Inflammation: benefits: some inflammatory molecules promote the induction of tumour immunity, depends on site of recruitment during the developmental stages of cancer. Il-1 beta promotes development of immune responses against establishment of tumours: facilitates tumour recognition. Involved in tumour escape: activated by cancer-derived products such as vegf, suppresses tumour immunity.
