MICR 360 Lecture 15: MICR 360 6:1
22 Dec 2018
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Document Summary
Class iii genes: encode other non mhc proteins like complement and cytokines (tnf) Not exp on cell memb, only found in cytoplasm in vesicles. Helps peptide binding to mhc ii molecules- during ag processing inside endosomal compartment. Exp on cell memb as a heterodimer (a-chain from abc genes + b-2 microglobulin no encoded by mhc complex) Highly polymorphic (a1+2)- allelic variation in binding cleft. Cd8 co-r on t cells binds a2-3 regions. Cd= cluster of differentiation, cell surface molecule rec by unique monoclonal ab. Hla-dp, dq, dr exp on cell memb as monomer (non-covalently bound) Highly polymorphic at a1 and b1 domains (binding cleft), 1 a from 1 chain can bind w b from another chain/loci. Interact w cd4 on t cells, cd4 co-r binds to. Mhc i: cd8 (heterodimer) binds a2/3, ends of peptide buried in cleft (8-10 aa) Mhc ii: cd4 (monomer) co-r binds b1/2, ends of peptide not buried (13-18aa)
