PHGY 350 Lecture Notes - Lecture 5: Major Histocompatibility Complex, Stellar Classification, Thymus
22 Sep 2016
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Binds to immune cells at fc (constant) end. Igg = immunoglobulin type g: 75% of plasma antibodies, able to cross the placenta. Iga = immunoglobulin type a: present in secretions (milk, saliva, bile) Ige = immunoglobulin type e: prominent in allergic responses. Igm = immunoglobulin type m: primary responders, blood group reactions. Igd = immunoglobulin type d: what they do is still a mystery and not well defined yet. Antibody functions act as opsonins (they have opsonic function) bind leukocyte to a microbe agglutination (clumping) of antigens: prevent pathogen from entering cells, very good signal for other white blood cells to come along activate immune cells. Degranulate mast cells ige sticks into mass cells, antigen acts as antenna and causes release of histamines etc. Do not make antibodies, produce cell-mediated response (cell response, cells have to be in contact with cells) Mature in thymus gland upper thoracic, lower neck. Present on all nucleated cells (not on rbcs)
