BCH 361 Lecture 7: TCA Cycle

115 views11 pages

brownbutterfly767

13 Feb 2017

School

Department

Course

Professor

For unlimited access to Class Notes, a Class+ subscription is required.

Document Summary

Hub of metabolism - cycle generates intermediates to be used in biosynthesis reactions. Glycolysis of 1 glucose generates 2 atp, as well as 4 electrons (on 2 hydride molecules) collected by 2 nad+ --> 2 nadh. Pyruvate moves into mitochondria to undergo decarboxylation to form acetyl coa. Coa will then undergo a series of oxidation rxns collectively called the tca cycle. This process releases a co2 + 2 e- (collected by a nad+ -> nadh). Each tca cycle, for 1 pyruvate, produces 2 co2, 1 gtp and 8 e- are collected, 6 of which are collected by 3 nad+, 2 of which are picked up by fad. Provide a means by which any fuel molecule (contains c + can be oxidized to obtain e -) that contains an acetyl group can be oxidized to form atp molecules. Provide the building blocks needed to form biological molecules such as nitrogenous bases, aa, glucose, and poryphorin molecules.

Related Questions

2. In many cases, cellular signal transduction is mediated by a membrane-associated G-protein complex. Which is not right about this protein complex?

A) The complex is made of Î±-, Î²-, and Î³-subunit.

B) The G_sÎ±-subunit has a GTPase activity.

C) Depending on the receptor types, either G_sÎ±-subunit or G_iÎ±-subunit is used.

D) Signal transduction through G-proteins ultimately regulates protein phosphorylation.

E) None of the above.

3. Which statement is not right about the pyruvate dehydrogenase?

A) This enzyme is located in the mitochondria.

B) This enzyme consists of three different enzymatic subunits (E1, E2, and E3).

C) This enzyme catalyzes the reaction: Pyruvate + CoA + NAD Â® Acetyl-CoA + CO₂ + NADH

D) This enzyme also uses TPP (thiamine pyrophosphate), lipoic acid, and FAD as cofactors.

E) Despite its complexity, this enzyme is not an important regulation point of TCA cycle.

4. To maintain a proper rate of the TCA cycle, oxaloacetate is replenished periodically. To increase [oxaloacetate], ___X____ is turned on but the TCA cycled is turned off by phosphorylation of __Y__.

A) X = Glyoxylate cycle :::::: Y = isocitrate dehydrogenase

B) X = Glyoxylate cycle :::::: Y = isocitrate lyase

C) X = Q cycle :::::: Y = isocitrate dehydrogenase

D) X = Q cycle :::::: Y = isocitrate lyase

E) None of the above.

5. Assume you have three NADH and one FADH₂. Calculate the total numbers of H⁺ pumped into the inter-membrane space and the maximal number of ATP produced inside the matrix.

A) 40 H⁺ and 12 ATP
B) 40 H⁺ and 11 ATP
C) 36 H⁺ and 12 ATP

D) 36 H⁺ and 11 ATP
E) None of the above.

1. Which is an w-3 fatty acid?

A) B) C) D) E) None ofthese

2. In many cases, cellular signal transduction is mediated by amembrane-associated G-protein complex. Which is not right aboutthis protein complex?

A) The complex is made of Î±-, Î²-, and Î³-subunit.

B) The G_sÎ±-subunit has a GTPase activity.

C) Depending on the receptor types, eitherG_sÎ±-subunit or G_iÎ±-subunit is used.

D) Signal transduction through G-proteins ultimately regulatesprotein phosphorylation.

E) None of the above.

3. Which statement is not right about the pyruvatedehydrogenase?

A) This enzyme is located in the mitochondria.

B) This enzyme consists of three different enzymatic subunits(E1, E2, and E3).

C) This enzyme catalyzes the reaction: Pyruvate + CoA + NAD Â®Acetyl-CoA + CO₂ + NADH

D) This enzyme also uses TPP (thiamine pyrophosphate), lipoicacid, and FAD as cofactors.

E) Despite its complexity, this enzyme is not an importantregulation point of TCA cycle.

4. To maintain a proper rate of the TCA cycle, oxaloacetate isreplenished periodically. To increase [oxaloacetate], ___X____ isturned on but the rest step of TCA cycled is turned off byphosphorylation of __Y__.

A) X = Glyoxylate cycle :::::: Y = isocitrate dehydrogenase

B) X = Glyoxylate cycle :::::: Y = isocitrate lyase

C) X = Qcycle :::::: Y = isocitrate dehydrogenase

D) X = Qcycle :::::: Y = isocitrate lyase

E) None of the above.

5. Assume you have three NADH and one FADH₂.Calculate the total numbers of H⁺ pumped into theinter-membrane space and the maximal number of ATP produced insidethe matrix.

A) 40 H⁺ and 12 ATP
B) 40 H⁺ and 11 ATP
C) 36 H⁺ and 12 ATP

D) 36 H⁺ and 11 ATP
E) None of the above.

I put the following

1. D

2. D

3. E.

4. idk

5. idk

Can someone help me out for 4 & 5 and reassure I got 1-3correct! Thanks

sangriarabbit412

1. During the TCA cycle, four reactions occur in which a pair of electrons are transferred from a substrate to an electron accepting coenzyme. These reactions are catalyzed by?

2.During the TCA cycle, four reactions occur in which a pair of electrons are transferred from a substrate to an electron accepting coenzyme. These reactions are catalyzed by?

3.Potent respiratory poison, including carbon monoxide, azide and cyanide have their toxic effect by binding to the heme a3 site of _____.

4.The first step in the TCA cycle is the condensation of the two-carbon acetyl group with a four-carbon _____ to form a six-carbon citrate molecule?

5.The inner mitochondrial membrane is virtually devoid of ____, and and rich in ____, which are characteristics of bacterial plasma membranes.

6.Iron sulfur centers are joined to the protein by linkage to a sulfur atom of a/n ___.

7.Decarboxylation of pyruvate and transfer of the acetyl group to CoA , along with the reduction of NAD₊ is catalyzed by ___.

8.When FADH₂ is the electron donor, electrons are passed directly to ____ in the respiratory chain

9.With the exception of ____, all of the redox centers within the respiratory chain that accept and donate electrons are prosthetic groups.

10.It iis evident fromt eh net equation fo the TCA cycle that the primary products of the pathway are the reduced coenzymes _____.

11. Complex III catalyzes the transfer of electrons from ___ to ___.

12. The passage of a pair of electrons from NADH to ubiquinone in the respiratory chain is accompanied by movement of roughly four protons from (the) ___ to (the) ___.

13. When NADH is the electron donor, electrons pass the respiratory chain by means of ____.

14. The matrix of the mitochondrion has a gel-like consistency owing to the presence of a high conentration of _____.

These are questions I missed on a quiz the instructor does not post what the answers should be and has not responded to my emails please help.

Thanks,

Amber

BCH 361 Lecture 7: TCA Cycle

Document Summary

Get access

Related Documents

BCH 361 Lecture 9: Oxidative Phosphorylation

BCH 361 Lecture Notes - Lecture 3: Ethanol Fermentation, Alcohol Dehydrogenase, Acetaldehyde

BCH 361 Lecture Notes - Lecture 8: Flavin Mononucleotide, Citric Acid Cycle, Rieske Protein

Related Questions