BLG 888 Lecture Notes - Lecture 2: Phosphodiester Bond, Pyrimidine, Purine
16 Jan 2017
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Document Summary
Nucleotides undergo condensation reactions to form nucleic acids. 3" carbon attaches to phosphate group- there is 5" to 3" polarity. T-a have 2 hydrogen bonds, g-c have 3 hydrogen bonds oligonucleotide = short nucleic acid chain containing less than 50 nucleotides polynucleotide = chain containing over 50 nucleotides. Catg can be written as cpaptpgp- the little p is a phosphodiester bond, indicates 5" end while oh indicates 3" end the nucleic acid chains run antiparallel. Base composition of dna varies from species to species. Dna specimens isolated from different tissues of the same species have the same base composition. Proteins can bind in grooves and there are specific recognition sites there are 3 types of dna: b-dna, a-dna, and z-dna. B-dna and a-dna are right handed helixes while z-dna is left handed. A-dna is more compact than b-dna, it is shorter and normally found in rna and some dna.
