BLG 10A/B Lecture Notes - Lecture 17: Red Blood Cell, Hematocrit, Platelet
10 Jun 2019
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Formed elements: living cells within plasma matrix: erythrocytes ------- hematocrit value ------ 45%. Leukocytes and platelets ---- buffy coat ---- <1%. Blood loves laminar flow and smooth surfaces: test-tube is coated with heparin to prevent coagulation. Blood is sticky, opaque, and metallic in flavour: varies in colour according to oxygen concentrations, oxyhemoglobin: high oxygen concentration, scarlet red, deoxyhemoglobin: low oxygen concentration, dark red, carbaminohemoglobin: carbon dioxide in blood. ph of 7. 35-7. 45. ~8% of body weight: males: 5-6 l. Functions of blood: distribution of, oxygen, nutrients, metabolic wastes, hormones. Regulation of: body temperature, ph, fluid volume. Proteins are produced by the liver: albumin: 60% of plasma proteins: makes sure that fluid stays in system and not in tissues, globulins. Biconcave discs, depressed centers, anucleate, no mitochondria: atp production is anaerobic. Spectrin makes rbcs highly flexible and deformable to squeeze through capillaries. Filled with hb for gas transport: major contributor to viscosity. Binds reversibly with oxygen: males: 13-18 g/ 100 ml.
