BLG 307 Lecture Notes - Interleukin 10, Natural Killer Cell, Gata3

24 views3 pages
Published on 28 Jan 2013
antigen recognition does not occur at site of entry, but usually in lymph nodes/spleen
activated T cells then migrate to target tissues
IL2R – complex of αβγ that associate non-covalently
essential for immune function, as its chains are involved in MANY ILR’s
IL2 is not absolutely necessary b/c other cytokines can replace function
ag:MHC complex binding to TCR triggers IL2R assembly/synthesis
ensures that IL2 only activates clonal expansion of ag-specific cells
ag:MHC complex binding to TCR can also stimulate IL2 SYNTHESIS
some cells can make IL2 autocrine/endogenous can be used
can’t make IL2 paracrine/exogenous IL2 necessary
other IL’s
IL4 – growth factor, similar to IL2
IL7 – growth factor for immature T cells (CD4-, CD8-) in thymus
produced by thymus stromal cells
ILR’s are coupled to tyrosine kinases
Jaks phos. STATs (TF’s)
Unlock document

This preview shows page 1 of the document.
Unlock all 3 pages and 3 million more documents.

Already have an account? Log in

Get OneClass Notes+

Unlimited access to class notes and textbook notes.

YearlyBest Value
75% OFF
$8 USD/m
$30 USD/m
You will be charged $96 USD upfront and auto renewed at the end of each cycle. You may cancel anytime under Payment Settings. For more information, see our Terms and Privacy.
Payments are encrypted using 256-bit SSL. Powered by Stripe.