BLG 311 Lecture Notes - Lecture 3: N-Terminus, Lipid Bilayer, Protein Filament
24 May 2016
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Document Summary
Water channels that greatly increase the cells permeability to water; common in eukaryotes but not prokaryotes (they are small) Prominent in cells required for water transport (kidneys etc. ) Six helical transmembrane segments, and four of these are put together. Two strategically placed asparagine amino acids that tethers the central water which prevents participating in a proton relay. Typical ion channel; fluctuates between closed and open states. Structure of cftr (draw and demonstrate that i understand the structure draw the schematic. Include the n and c terminus to show that we know it"s a protein draw the five domains, okay with circle for each domain show the flow of cl- ions through the protein outside the cell. Include the atp in the atp binding domains (know that only site two is active) show the lipid bilayer to show inside and outside of cell.
