BMS 860 Lecture Notes - Lecture 4: Juxtacrine Signalling, Gtpase, Axin1

• School: Ryerson University
• Department: Biomedical Sciences
• Course: BMS 860
• Professor: Radulovich

Document Summary

Her2- receptor protein signaling pathways in human cancers. Signaling pathway: group of proteins in a cell that work together to control one or more cell functions, such as cell division or cell death. Sig(cid:374)ali(cid:374)g tra(cid:374)sductio(cid:374): tra(cid:374)s(cid:373)issio(cid:374) of (cid:373)olecular sig(cid:374)als fro(cid:373) a cell"s exterior to its i(cid:374)terior which ultimately results in a cellular response. About 500 pathways have been found in human cells cells communicate. Cell to cell communication is an important process that allows cells to pass signals to one another. Cell communication is crucial in coordinating cellular activities. Cell communication is crucial in maintenance of the tissue architecture. Villi in the intestinal epithelium regenerates every 4 hours- tightly regulated process, and the number of cells and position of cells need to be controlled cells communicate via chemical signals. Chemicals are usually proteins, can be light. Only certain receptors will bind certain ligands. Response can be cell proliferation, cell death, self renewal forms of signaling.