PAT 20A/B Lecture Notes - Lecture 4: Quadriceps Femoris Muscle, Antibiotics, Minocycline

• School: Ryerson University
• Department: Pathotherapeutics
• Course: PAT 20A/B
• Professor: Susan Bishop

Document Summary

Unpleasant sensory and emotional experience associated with actual or potential tissue damage, and with many diseases or health conditions. Acute pain sudden and usually subsides when treated e. g. a headache. Persistent pain long lasting or recurring, lasting 3 months or longer. More challenging to treat because changes occur in the nervous system (tolerance) that often requires increasing drug doses. Discuss the neurology of pain transduction (including the arachidonic acid pathway) transmission, perception and modulation. Transduction: begins in periphery (skin, subcutaneous tissue, somatic structures) where primary afferent neurons (nocireceptors) are scattered. These free nerve endings are sensitive to harmful or potentially harmful, tissue damaging, chemical, mechanical, or thermal stimuli: the stimulus causes the release of numerous chemicals, and these chemicals initiate conversion of the stimulus to an impulse. Transmission: involves the transmittal of the pain impulses along pain fibres to activate pain receptors in the spinal.