PAT 20A/B Lecture Notes - Lecture 2: Myoglobin, Chronic Kidney Disease, Shortness Of Breath
7 Nov 2017
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Calcium excretion decrease with bone cancer, thiazide chloride, diuretics. Lithium usage ( affect parathyroid phosphorus decrease, ca increase) Other: malignancy- lead to bone destruction from tumor invasion, or tumor secretion of parathyroid protein, vitamin d overdose. Acute pancreatitis lead to lipolysis (pancreatitis produces fatty acid that combines with ca2+ ca. Using meds (magnesium supplements, laxatives, loop diuretics, ca binders) Multiple blood transfusion citrate used to anticoagulate blood binds to ca. *sudden alkalosis- high ph. increase calcium binding to protein decrease amount of ionized calcium, but still have the total normal serum calcium level. Intervention: calcitonin, biophosphonates, prostaglandin synthesis, dialysis, loop diuretics, hydration with isotonic saline infusion, mobilization with weight bearing activity, w/ malignancy, drug of choice: pamidronate (aredia) inhibits the activity of osteoclast. Sign of chvostek"s sign- twitching of face, or lips, tapping the facial nerve infront of ear. Iv or oral calcium supplements- never give im ( it precipitate muscle)
