PSY 605 Lecture 2: PSY 605 Lcture 2: PSY 605 Lecure 2: L2, E1 - Factors Modifying Drug Dos
Document Summary
L2, e1 - factors modifying drug dosage and response. Factors related to the animal: species, breed, individual, body weight, age, sex, temperament, idiosyncrasy, hypersensitivity, disease, tolerance. Factors related to the drug: route of administration, timing of administration, cumulation, drug-drug interaction. Differences in species (big picture: anatomical, physiological, biochemical. If you give a drug orally in one species vs in a different species the absorption ti monogastric animal it"s usually 30 minutes to an hour. In a ruminant it could tak dose is going to be different and the route is going to be different. Another fac might deactivate the drug or whatever - dose has to be different and rate of m different. Examples of factors relating to species that modify drug dosage and response tion time can vary greatly. In a ld take a day or two. Therefore the r factor could be that the rumen f metabolism is going to be se.
