BISC 202 Lecture Notes - Lecture 21: Punnett Square, Epistasis, Penetrance

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Bisc202 lecture 21: modified f2 ratios from gene pair interactions. If the f1 offspring are not all wild type (non-complementing), they are alleles for the same gene. This allows us to study how single-gene alleles interact. For monohybrid crosses, the phenotypic ratio gives valuable information: 3:1 = one allele is completely dominant. 1:2:1 = alleles show incomplete dominance or codominance. 2:1 = one allele has recessive lethality. Predict and determine the phenotypic ratio of f2 progeny as some interactions will produce characteristic phenotypic ratios. If unlinked genes and not lethal, we expect a 9:3:3:1 ratio (no major interactions between genes) If real data is given we can convert to a ratio by dividing the total progeny by. 16, and then taking each count and dividing by that number to convert it into a ratio out of 16. Can use punnett square or the branching diagram to predict the f2 phenotypic ratio.

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