BISC 202 Lecture Notes - Lecture 33: Zygote, Chromosomal Inversion, Centromere

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Chromosome structures can change in a variety of different forms of rearrangement including: When a piece of chromosome is reversed in direction and includes 2 types. Paracentric = to one side or the other side of the centromere (all one side) Pericentric = breaks span the centromere (one on each side) Changes in arm ratios occur for some pericentric inversions. Arm ratio refers to the length of the dna sequence of an arm from the centromere. Inversions can cause a variety of structural changes in dna. If breakpoints occur between genes, there may be no visible phenotype change (not observable) Breakpoints within genes can create fusions that could be recessive lethal or other observable phenotype changes. These inversions may not cause phenotypic changes but can have other consequences. Recombination can be suppressed within the inverted region. In meiosis, the homologous chromosomes will still pair up and the correct regions will synapse but it causes chromosomal looping (seen in electron microscope)

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