BPK 205 Lecture Notes - Lecture 31: Central Nervous System Depression, Renal Compensation, Proximal Tubule
5 Nov 2017
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Objectives: describe fluid & electrolyte homeostasis in the body. 2. 2l consumed + 0. 3l made (metabolism) 0. 9l sweat/breath + 1. 5l urine + 0. 1l feces. Kidney conserve or remove body fluid by h2o reabsorption: osmolarity difference along nephron and in interstitium around nephron important for determining concentration of excreted urine (300 mosm, 300 mosm, 300 mosm, 600 mosm, 900 mosm, 1200 mosm) Vasopressin regulates water reabsorption in the collecting duct. Decreased bp sensed by carotid + aortic baroreceptors . Decrease atrial stretch (low blood volume) atrial stretch receptors . Osmolarity greater than 280 mosm hypothalamic osmoreceptors . Hypothalamus make + release adh adh act on receptors on collecting duct epithelium aquaporins on apical membrane increased water reabsorption: aldosterone regulates na+ reabsorption in the distal tubule and collecting duct. Steroid hormone, made in/released from adrenal cortex, acts on distal tubule + collecting duct. Low bp (angiotensin ii) renin-angiotensin-system (ras) . High [k+] (hyperkalemia) (very high osmolarity inhibit)
