BPK 205 Lecture 30: BPK 205 Notes Lecture 30

• School: Simon Fraser University
• Department: Biomedical Physio & Kines
• Course: BPK 205
• Professor: Nadine Wicks

Document Summary

Objectives: describe the regulation of glomerular filtration rate (gfr) Increase afferent arteriole r decrease in flow decrease in ph decrease gfr. Increase efferent arteriole r (cid:271)lood (cid:862)pooli(cid:374)g(cid:863) i(cid:374) glo(cid:373)erulus increase ph + gfr. Describe how reabsorption is driven by movement of na+ Reabsorption = mostly in the proximal tubule; transepithelial transport or paracellular pathway. Electrochemical gradient na+ move into cell via enac (epithelial na+ channel) passively na+ pumped out basolateral side via na-k-atpase. Filtration = portions of blood plasma is filtered out at the glomerulus by diffusion. Reabsorption = portions of filtrate is reabsorbed back into kidney or the systemic circuit. Secretion = some volume of blood plasma is put back into nephron; removes organic compounds from body (creatinine, urea, nh4. Excretion = filtrate reaches collecting duct where no modification happens, and is excreted out of the body; urine; normally no glucose, amino acids, other useful metabolites since reabsorbed.