BPK 305 Lecture Notes - Lecture 1: Intercalated Disc, Thrombin, Syncytium

• School: Simon Fraser University
• Department: Biomedical Physio & Kines
• Course: BPK 305
• Professor: Thomas Claydon

Document Summary

Hematopoiesis (stem cells-> blood cells in bone marrow: 75% of cells produced are leukocytes (wbc) b/c only lives hours-days, erythrocytes (rbc) live 90-120 days, regulated by certain types of cytokines. Rbc- requires hb (which is made from fe/b12/folic acid: hb has 4 globin subunits, each subunit has a heme group (fe, hb binds to 4o2 co-operatively (binding of 1o2 facilitates the binding of another) > gives the sigmoid shape in po2 vs %hb sat. graph: hbo2 affinity is defined by po2 at which hb is 50% saturated. Hypochronic (low hb due to fe deficiency) Megaloblastic, hemolytic (fragile rbc), aplastic (low rbc production) Neutrophils- make up 50-70% of wbc and neutralize foreign substances. Basophils- form mast cells, releases histamine, mediate allergic response/ inflammation: monocytes- form into diff types of macrophages, antigen presentation, lymphocytes- b cells, t-cells, natural killer cells. Circulation: systemic-> vena cava-> ra-> tricuspid valve->rv-> pulmonary valve-> pulmonary circulation-> la-> mitral valve-> lv->aortic valve -> aorta.