BPK 305 Lecture Notes - Lecture 14: Anterior Interventricular Branch Of Left Coronary Artery, Coronary Circulation, Circumflex Branch Of Left Coronary Artery
29 Oct 2017
School
Department
Course
Professor
Document Summary
Autoregulation of blood flow: pressure-flow relationship is supralinear in elastic vessels because increased pressure leads to increased radius and decreases resistance, autoregulation happens in resistance vessels, ex. brain, kidney, skin, coronary. Increased flow -> increased stretch -> reflex constriction. Metabolic: decreased flow -> metabolites build up, decrease po2 -> local vasodilation. 1: sympathetic stimulation -> vasoconstriction, parasympathetic stimulation -> vasodilation. Adrenergic receptors sympathetic stimulation: 1 = cardiac. Increase contractility: higher affinity for ne than epi, 2, 2 = bronchioles, bronchodilation, 2 = large skeletal muscle vasculature and coronary arteries, vasodilation (adrenaline) Increase blood supply during exercise: much higher affinity for epi than ne, 1 = vascular smooth muscle, profound vasoconstriction, higher affinity for ne than epi. Myocardial o2 consumption has a linear dependence on coronary blood flow (i. e. deliver: double the blood flow = double the oxygen consumption by the heart. His, and conducting tissue: coronary circulation drains into the right atrium via the coronary sinus.
