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HSCI 216 (49)
Lecture

lecture2.docx

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Department
Health Sciences
Course Code
HSCI 216
Professor
Pablo Nepomnaschy

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HSCI216: LECTURE II Friday May 11, 2012  Tests will ask about facts that are logical, therefore understand concepts!  Multiple choice exams (40-45 questions) 2 can be true, one is stupid – use process of elimination  Go through notes, questions in questionnaires*, videos etc.  Evolution: change in the collective information contained in a populations genetic makeup. o Start with a population with some info on one generation, then move to a next generation and something changes  causing evolution o How does it happen? HEREDITY o Heredity: transmission of information from one generation to the next. *  Basic mechanisms involved in the transfer of genetic information: o DNA is organized in chromosomes (23, there are 2 copies) o During cell cycle mitosis occurs (go over mitosis)  how DNA goes from one cell to the next o Meiosis: how DNA is inherited from person to person (go over meiosis)  divide into gametes cells (somatic cells – because “soma” is body)  How does genetic material change across generations… o Mutation: change in the sequence of bases of DNA (review structure of DNA) o Variation!  Sources of variation  Mutation  Sex  Meiosis (recombination etc.) o Meiosis (huge source of variation)  Recombination: happens when making gametes, the 2 chromatids get together, when they cross they are sticky and they will get stuck. Thus causing variation. They do not always cross at the right place causing change. This increases number of genetic combinations  Then there is a process of combination of different gametes o 98.5% of human genome does not code for protein  because there are a lot of regulatory systems in the DNA (the expression of the genes is going to determine how the body works) o not all base pairs are created equal  *phenotype does not only include physical features but behavior, personality etc. (what we can perceive from them) ie: if body produces much cortisol then we will react a lot, vise versa, thus showing how environment affects us genetically. ie: womens hormonal levels during mentranaul cycle is part of her phenotype based on the genes she has.  Not as “self contained”  Mendel Slides: o Alleles do not mix! o Dominant allels masked recessive ones  distinction between phenotype and genotype o Genotype: genetic configuration o Phenotype: outwards  Punnett square: everyone is hetrozyphis(?), this explains 3:1 ratio o Phenotypic frequencies and genetic frequencies! Know the differences*  Some traits travel always by themselves, some traits always travel together o Genes that are close together within the chromosome are more likely to travel together  Monogenic disorders: o They are disorders that depend on one particular gene o Pedigree fo
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