HSCI 212 Lecture Notes - Lecture 10: Deoxycholic Acid, Influenza A Virus Subtype H3N2, Formaldehyde
9 Aug 2018
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Document Summary
Serology: scientific study of plasma serum and other bodily fluids; diagnostic identification of ab in serum (ab formed in response to infection) Sero-survey: test of blood serum from group of individuals to determine seroprevalence (eg. ab to hiv) Hemagglutin (ha): allows virus to enter cells with sialic acid. Neuraminidase (na): makes it possible for virus to leave cell when budding. Antigenic drift: virus enters host cells, mutations in antigen genes occur during replication within. Ha needs 8-10 amino acid changes for new vaccine (if ha gene changes, antigen it encodes for host cell, virus differs slightly from original, exits cell changes and changes shape, so ab don"t match) Antigenic shift: viruses 1 and 2 enter host cell, genes and antigens from both are incorporated into new virions, virus 3 is very different. Neuraminidase inhibitors (block release of virions from infected cells) Must be taken within 48 hours of infection.
