HSCI 323 Lecture Notes - Lecture 10: Dopamine Agonist, Growth Hormone, Mecasermin
29 Nov 2016
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LECTURE 10: endocrine system and Endocrine disruption
Growth Hormone
Somatostatin
- Inhibit release of GH and thyroid stimulating hormone (TSH) from anterior pituitary and insulin and glucagon
from the pancreas
Octreotide
- Synthetic drug
- Use: treatment of carcinoid syndrome and acromegaly
Somatropin
- Recombinant GH analog
Mecasermin
- Recombinant IGF-1 analog
- Use of Meca and somatropin:
o Pituitary dwarfism- lack of GHRF or IGF generation or action
Pegvisomant
- GH antagonist
- Gigantism in children and acromegaly in adults- overproduction of GH caused by pituitary tumours
Prolactin
Bromocriptine
- Dopamine receptor agonist
- Use: treat prolactin overproduction (hyperprolactinaemia)
Glucocorticoid analogs
Prednisone
- Used for replacement and substitution therapy for severe inflammation
Dexamethasone
- Found in many over the counter medication such as cough syrup
Inhibitors of Adrenocorticosteroid Synthesis
Kenoconazol
- Inhibit P450 enzyme, cant covert cholesterol to adrenal and gonadal hormones
Metyrapone
- Inhibit 11-beta-OH, prevent cortisol and corticosterone formation.
Mineralocorticoids
Fludrocortisone
- Increases Na reabsorption in distal tubes
- Increase K and H efflux into the tubules
- Used with glucocorticoid in replacement therapy
Eplerenone
- Competitive antagonist of aldosterone
- Treatment for Co’s Sydroe hyperalderosterois
Synthetic analogs of ADH
Desmopressin
- Longer half life than VP
- V2 selective, fewer pressor effects
- ADH effect: pressor effect= 2000:1
- Use: Diabetes insipidus (water imbalance), enuresis, blood coagulation disorders
VP/ADH
- Vasoconstriction (V1A effect)
- Ventricular fibrillation (counteract vasodilation due to lack of ADH)
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Document Summary
Inhibit release of gh and thyroid stimulating hormone (tsh) from anterior pituitary and insulin and glucagon from the pancreas. Use: treatment of carcinoid syndrome and acromegaly. Use of meca and somatropin: pituitary dwarfism- lack of ghrf or igf generation or action. Gigantism in children and acromegaly in adults- overproduction of gh caused by pituitary tumours. Used for replacement and substitution therapy for severe inflammation. Found in many over the counter medication such as cough syrup. Inhibit p450 enzyme, cant covert cholesterol to adrenal and gonadal hormones. Increase k and h efflux into the tubules. Use: diabetes insipidus (water imbalance), enuresis, blood coagulation disorders.
