BIOL 1550 Lecture Notes - Lecture 4: Toxic Epidermal Necrolysis, Renal Function, Liver Function Tests
Document Summary
Undesired response to drug : iatrogenic disease-illness produced by healthcare professional/situation. Decreased by adverse effects (adrs: adherence: taking a medication as it has been prescribed, detection of adrs, clinical trials, adr"s undetectable in early trials unless less than 1% frequency, takes 3-20 years to detect rare events. Types of adr"s: pharmacological : based on d-r interaction, predictable. Dependence: non-pharmacological : based on d-r interaction, not predictable. May gradually fade: may necessitate change of medication. Due to the actual effects of medication: overdose of drug. Substance dependence: compulsive use of drug despite negative social, health, emotional and economic impact, tolerance: require increases in dose for original effect, physical dependence: drug required for homeostasis, psychological dependence: person believes drug required for function. Sleeping pills (believe they need it to sleep) Carcinogenicity: 7 20 year onset (for tumor to grow after damage to the cell, various organs. Drug-specific: predict in vitro and with animals, monitor for years.
