BIOCH410 Lecture Notes - Lecture 1: G0 Phase, Ubiquitin, Transactivation
12 Feb 2020
School
Department
Course
Professor
Document Summary
Egf receptor singling, phosphorylation, ubiquitylation and endocytosis in tumours in vivo. Many cell surface recipes have a site of liana bidding domain. Another domain that fans the snide of the cell. Signal from outside of the cell to inside of the cell to the nucleus of the cell. Growth where cell gets stuck in a cell cycle: won"t divide. Adipocytes: hypertrophy as it takes in fat. Gpcrs can cross talk with growth factor receptors. Cancer happens when you have a critical number of mutations in key genes that is necessary for growth. That number of changes in just a matter of time. Stage ii: tumour has its own circulatory system. Stage iii: can become much much larger. Stage iv: start spreading and perform micro-metaststasis. Cells can go back from g0 phase and re-enter the cell cycle. Growth factors blocks blocker of cdk4 .
