BIOCH410 Lecture Notes - Lecture 5: Pleckstrin Homology Domain, Grb2, Protein Kinase B
12 Feb 2020
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Document Summary
Depending on the primary sequence of the sh@ domain it binds to di erent substrates. The ph domain: sos is able to ind the phospholipids n the cell membrane. To couple to grab and tp bring was to the cell membrane. Pip3 can recruit proteins with a nity for phospholipids . Shc has ability to couple with phsphotyrosine residues. Src: has tyrosine kinase domain, sh2 domain and sh3 domain. Sh3 can enae src to fold sh3 domain binds to proline rich domain of src. Transcription of tsat factors will be enables by dna binding domains. When stat factor recruited to leptin it can be phosphorylated. The sh2 domain can attach to a phsphtyrisone residue . The to monomers contain sh2 and phosphptyrosine resides. The homier moves to the nucleus where it can . U: leimination of wigan receptor comely through endocytic tra cking. Egfrs can form homodimers with another egfr and also heterodimers with other receptors.
