BIOL201 Lecture Notes - Lecture 19: Tubulin, Insulin, Protein Kinase B
22 Jan 2016
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Cdk can get activated: cdk activating kinase* cdk has 3 sites: 2 inhibitory and 1 for activation. Kinesin related proteins push centrosomes apart, similar to polar mt during anaphase b. kinesins are walking to slide away from each other. Lamin (inside the nucleus, makes up the nuclear lamina- phosphorylated by mitotic cdk to induce fragmentation of the nuclear envelope. 3 key activities: kinetochore-mt: active during anaphase a- responsible for pulling the chromosomes from the center of the cell to spindle poles- 2 molecular motors. One in the kinetochore and the other at the spindle pole- pulls chromosomes. These pushes the spindle poles away from each other: astral mt: walk along the mt from the + to ends on the mt of the spindle poles. All responsible for the separation of the chromosomes* Clicker: taxol is a drug that stabilizes microtubules. What is the expected impact on mitosis: the cell will arrest on the verge of anaphase.
